Wearing an off-the-shoulder jacket with matching trousers and long, geometric earrings designed by Kim Jones, Moore opened the show and was later joined by supermodels Naomi Campbell, Cara Delevingne, and Christy Turlington.
The show also featured appearances by Kate Moss and her 18-year-old daughter Lila.
Last fall, Moore, 58, appeared during Rihanna’s Savage X Fenty fashion show, though her Fendi appearance marks her runway debut.
The Ghost actress had worked with Jones, who is Fendi’s artistic director, before; she posed for a book of portraits in 2019 wearing Jones’s designs.
“Thank you to the wonderful cast that made this happen true friends and family,” designer Jones wrote on Instagram following the show. “I love you all !”
Jones also addressed the ongoing Covid-19 pandemic and thanked “those who ensured that all safety protocols were followed and special measures set in place to allow this to happen”.
Moore also thanked the designer, writing on her Instagram Story, “Thank you @fendi @mrkimjones for having me. Congrats on a beautiful show.”
The actress, who is best known for appearing in film classics like A Few Good Men, Indecent Proposal, and G.I. Jane, released a memoir, Inside Out, in 2019.
“I wanted it to be just human and about our humanity, and to be an opportunity to connect,” she told The Independent last year. “The only way I could do that was just to be as truthful and honest about my experience as I could be. And it was healing.”